negative regulation – Communicable Diseases Research

Differential interferon-α subtype induced immune signatures are associated with suppression of SARS-CoV-2 infection

차등 인터페론-α 아형 유도 면역 시그니처는 SARS-CoV-2 감염 억제와 관련이 있습니다

420

Published on 2022-02-072022-09-10
Journal: Proceedings of the National Academy of Sciences of
[Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단,

An in silico analysis identifies drugs potentially modulating the cytokine storm triggered by SARS-CoV-2 infection

실리코 분석은 SARS-CoV-2 감염에 의해 유발된 사이토카인 폭풍을 잠재적으로 조절하는 약물을 식별합니다

Article

Published on 2022-01-312022-09-10
Journal: Scientific Reports
[Category] 신약개발, 유전자 메커니즘, 치료제,

[키워드] “cytokine storm” addition Analysis anti-inflammatory properties anti-inflammatory property approach BALF Bronchoalveolar lavage fluid cause causes Computational biology and bioinformatics connectivity COVID-19 COVID-19 mortality COVID-19 pandemic COVID-19 patient Cytokines Data mining dataset drug Effect expected female hormone glucocorticoid Glucocorticoids Health help human cell lines identify immune response immune responses in silico analysis in vitro data Inflammatory Map MEK inhibitor modulating molecules Mortality negative regulation pathology pathway Pathways PKC predicted reveal SARS-CoV-2 SARS-COV-2 infection small molecule Small molecules supported the cytokine storm these compounds Transcription Transcriptome transcriptomic data Treatment triggered
[DOI] 10.1038/s41598-022-05597-x PMC 바로가기 [Article Type] Article

Regulation of gliotoxin biosynthesis and protection in Aspergillus species

아스 페르 길 루스 종에서의 글리 톡신 생합성 및 보호의 조절

Research Article

Published on 2022-01-182022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] Analysis approach aspergillosis Aspergillus Aspergillus fumigatus Aspergillus oryzae best cause colonisation component conserved disease Disease progression enzyme expresse expression expression of gene expression pattern facilitate fungal Genes genetic determinant genetic determinants Genome Glia homolog homologs human immune response identify Immune cell impair include involved kojic acid mechanism metabolism modulated mycotoxin negative regulation neutralising nidulan nidulans observé occur Occurrence pathogenicity producing regulate required responses RNA-sequencing screened secrete secretion sensitivity significantly sulfur Taking TFS toxic effect toxic effects transcription factor transcription factors transcriptional transcriptional response virulence
[DOI] 10.1371/journal.pgen.1009965 PMC 바로가기 [Article Type] Research Article

Forecasting of phenotypic and genetic outcomes of experimental evolution in Pseudomonas protegens

슈도모나스 단백질 겐에서 표현형 및 유전 적 결과의 예측

Research Article

Published on 2021-08-052022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] adaptation adaptive addition Air-liquid interface Amino acid Bacterial Biological Biology can not Cancer Cellulose changed Climate change colonize condition conditions conserved core dependent on develop Diseases disrupt Evolution expected experiments Factor fitness followed by Forecasting Genetic Genotype growth hot spot identity Infectious diseases lack majority mathematical mathematical model microbe microbes model system model systems MOST motility mutant mutants Mutation mutation rate Mutation rates mutations negative regulation nucleotide outcome outcomes pathway phenotype Phenotypes phenotypic polysaccharide Population predict predictability predicted predicted gene predicted genes Predictive model prevented problems promoter regions Protein provide Pseudomona Pseudomonas Pseudomonas species Pseudomonas specy real time reduced Region resulting sequence tested Variation
[DOI] 10.1371/journal.pgen.1009722 PMC 바로가기 [Article Type] Research Article

ACE2 Down-Regulation May Act as a Transient Molecular Disease Causing RAAS Dysregulation and Tissue Damage in the Microcirculatory Environment Among COVID-19 Patients

ACE2 하향 조절은 COVID-19 환자의 미세 순환 환경에서 RAAS 조절 장애 및 조직 손상을 유발하는 일시적인 분자 질환으로 작용할 수 있음

Review

Published on 2021-07-012022-09-11
Journal: The American journal of pathology
[Category] 유전자 메커니즘, 진단,

[키워드] ACE2 Act acute respiratory syndrome acute respiratory syndrome coronavirus aldosterone angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 article Brain cause causing change changes in coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 damage disease Environment etiologic agent heart Infection Injury kidney Lungs manifestation mechanism molecular Molecular Disease multiform negative regulation offer organ organ systems pandemic pathophysiological provide RAAS Renin renin-angiotensin-aldosterone system respiratory responsible severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Transient Treatment variety vasculature
[DOI] 10.1016/j.ajpath.2021.04.010 PMC 바로가기 [Article Type] Review

SARS-CoV-2 Membrane Protein Inhibits Type I Interferon Production Through Ubiquitin-Mediated Degradation of TBK1

Immunology

Published on 2021-05-182022-11-01
Journal: Frontiers in Immunology
[Category] COVID-19, SARS,

Opposing functions of the plant TOPLESS gene family during SNC1-mediated autoimmunity

SNC1 매개 자가면역 동안 식물 TOPLESS 유전자 패밀리의 반대 기능

Research Article

Published on 2021-02-232022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] accumulate accumulation Activation addition additive effect amplitude approach Arabidopsis Autoimmunity bind cascade characterized complex complexes connection contribute Defense demonstrated detect Effect elevated event Evidence examined expression family members function Gene regulation Genetic genetic interaction growth immune Immune receptor immune receptors immune system Immunity in vivo include indicated Infectious disease Infectious diseases interact Interaction lead leads manifestation mechanism microbes mutant mutants Mutation mutations N-terminal domain negative regulation opposite organism Organisms overexpressing pathogen Pathogens phenotype Phenotypes plant plants Protein provide reductions reductions in regulate regulated Regulation Regulatory reported repress resistance gene response reversed shown specificity stunting titration transcriptional triggering upregulation variety while
[DOI] 10.1371/journal.pgen.1009026 PMC 바로가기 [Article Type] Research Article

Upregulation of DUSP6 impairs infectious bronchitis virus replication by negatively regulating ERK pathway and promoting apoptosis

Research Article

Published on 2021-01-112022-10-28
Journal: Veterinary Research
[Category] Coronavirus,

[키워드] activated antiviral drugs Apoptosis bronchitis cause Cell cell death component contagious disease Coronavirus infection correlated dominant negative DUSP6 ERK ERK1/2 expression Extracellular facilitate facilitated form IBV IBV infection impair Infectious Bronchitis Virus inhibitor Interaction investigated mutant negative regulation Pathogenesis pathway phosphatase Phosphorylation promoted reduced regulate Regulation Replication restrict shown Signaling signaling pathway siRNA suppressed target therapeutic These data Undetermined viral infection viral infections Viral load viral replication virus virus replication
[DOI] 10.1186/s13567-020-00866-x PMC 바로가기 [Article Type] Research Article

Tiotropium Is Predicted to Be a Promising Drug for COVID-19 Through Transcriptome-Based Comprehensive Molecular Pathway Analysis

Article

Published on 2020-07-202022-10-28
Journal: Viruses
[Category] COVID-19, SARS,

[키워드] activate acute respiratory syndrome addition Affect Airway inflammation Antiviral approaches bioinformatics caused Cell chronic obstructive complex Comprehensive COPD coronavirus coronavirus disease COVID-19 COVID-19 patients deregulated drug effective enrichment analyses epithelial expression Genes IL1B IL6 IL8 IMPROVE in vitro in vivo indicated Infection inhibit Interaction Lung fibrosis molecular molecular pathways negative regulation NFkB1 NFKB2 NHBE Ontology outbreak pathologic feature pathway Pathways Patient patients predicted pulmonary disease Pulmonary function Rapamycin reduced RELA RelB Remdesivir Replication rheumatoid arthritis RNA-Seq RNA-seq data SARS-CoV-2 shown significantly the SARS-CoV-2 therapeutic intervention tiotropium TNF upregulated upregulation
[DOI] 10.3390/v12070776 PMC 바로가기 [Article Type] Article

P200 family protein IFI204 negatively regulates type I interferon responses by targeting IRF7 in nucleus

Research Article

Published on 2019-10-112022-10-29
Journal: PLoS Pathogens
[Category] Coronavirus, MERS,